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Tablets

Recommended Dose

Late vs Missed Doses

Granules

The Recommended

The Recommended

The Recommended

Dose of TRIKAFTA

Dose of TRIKAFTA

Dose of TRIKAFTA

 

 

 

 

Your doctor will prescribe TRIKAFTA based on your age and weight. Make sure to take every dose of TRIKAFTA as prescribed. Because the 3 components of TRIKAFTA work together to treat the underlying cause, each and every dose matters.

Your doctor will prescribe TRIKAFTA based on your age and weight. Make sure to take every dose of TRIKAFTA as prescribed. Because the 3 components of TRIKAFTA work together to treat the underlying cause, each and every dose matters.

Your doctor will prescribe TRIKAFTA based on your age and weight. Make sure to take every dose of TRIKAFTA as prescribed. Because the 3 components of TRIKAFTA work together to treat the underlying cause, each and every dose matters.

For children age 6 through 11 years weighing less than 30 kg (~66 lb)

For children age 6 through 11 years weighing 30 kg (~66 lb) or more

and people age 12 years and older

For children age 6 through 11 years weighing less than 30 kg (~66 lb)

Morning Dose

Two light orange tablets

(elexacaftor 50 mg/tezacaftor 25 mg/ivacaftor 37.5 mg) with fat-containing food

(elexacaftor 50 mg/tezacaftor 25 mg/ivacaftor 37.5 mg) with fat-containing food

(elexacaftor 50 mg/tezacaftor 25 mg/ivacaftor 37.5 mg) with fat-containing food

About 12 hours later

Evening Dose

One light blue tablet

(ivacaftor 75 mg)
with fat-containing food

For children age 6 through 11 years weighing 30 kg (~66 lb) or more

and people age 12 years and older

Morning Dose

Two orange tablets

(elexacaftor 100 mg/tezacaftor 50 mg/ivacaftor 75 mg) with fat-containing food

(elexacaftor 100 mg/tezacaftor 50 mg/ivacaftor 75 mg) with fat-containing food

(elexacaftor 100 mg/tezacaftor 50 mg/ivacaftor 75 mg) with fat-containing food

About 12 hours later

Evening Dose

One light blue tablet

(ivacaftor 150 mg)
with fat-containing food

Each dose must be taken with fat-containing food to help your body absorb TRIKAFTA better

Each dose must be taken with fat-containing food to help your body absorb TRIKAFTA better

Each dose must be taken with fat-containing food to help your body absorb TRIKAFTA better

Examples of fat-containing foods include:

Examples of fat-containing foods include:

Examples of fat-containing foods include:

Whole-milk dairy products, such as:

Whole-milk dairy products, such as:

Whole-milk dairy products, such as:

Whole milk

Whole milk

Whole milk

Cheese

Cheese

Cheese

Yogurt

Yogurt

Yogurt

Eggs

Nuts

Butter

Meat

Peanut butter

Eggs

Butter

Nuts

Meat

Peanut butter

Get more food ideas

Talk to your healthcare provider about all of the medicines you take, as the dose of TRIKAFTA may need to be adjusted. It’s important to take TRIKAFTA exactly as your healthcare provider tells you.

Talk to your healthcare provider about all of the medicines you take, as the dose of TRIKAFTA may need to be adjusted. It’s important to take TRIKAFTA exactly as your healthcare provider tells you.

Talk to your healthcare provider about all of the medicines you take, as the dose of TRIKAFTA may need to be adjusted. It’s important to take TRIKAFTA exactly as your healthcare provider tells you.

Avoid foods and drinks that contain grapefruit while taking TRIKAFTA because they may affect the amount of TRIKAFTA in your body.

Avoid foods and drinks that contain grapefruit while taking TRIKAFTA because they may affect the amount of TRIKAFTA in your body.

Avoid foods and drinks that contain grapefruit while taking TRIKAFTA because they may affect the amount of TRIKAFTA in your body.

WHAT'S THE DIFFERENCE?

WHAT'S THE DIFFERENCE?

WHAT'S THE DIFFERENCE?

LATE vs MISSED DOSES

Late vs Missed Doses

Late vs Missed Doses

 

 

 

 

Each dose of TRIKAFTA should be taken about 12 hours apart, as your healthcare provider prescribed. But if you're late for your dose, you should know that you have 6 hours to take it before it becomes a missed dose. See below for guidance on what to do if your morning or evening dose is late.

Each dose of TRIKAFTA should be taken about 12 hours apart, as your healthcare provider prescribed. But if you're late for your dose, you should know that you have 6 hours to take it before it becomes a missed dose. See below for guidance on what to do if your morning or evening dose is late.

Each dose of TRIKAFTA should be taken about 12 hours apart, as your healthcare provider prescribed. But if you're late for your dose, you should know that you have 6 hours to take it before it becomes a missed dose. See below for guidance on what to do if your morning or evening dose is late.

Morning dose

If it's been 6 hours or LESS since the morning dose is usually taken:

  • Take the late dose with fat-containing food as soon as possible
  • Then take the next dose at the usual time with fat-containing food

If it's been MORE than 6 hours since the morning dose is usually taken:

  • Take the late dose with fat-containing food as soon as possible
  • Do not take the evening dose. Resume regular dosing schedule the next day

 

 

 

Evening dose

Evening dose

Evening dose

If it's been 6 hours or LESS since the evening dose is usually taken:

  • Take the late dose with fat-containing food as soon as possible
  • Then take the next dose at the usual time with fat-containing food

If it's been MORE than 6 hours since the morning dose is usually taken:

  • Do not take the late dose
  • Take the next morning dose at the usual time with fat-containing food

 

 

 

Do not take more than the usual dose of TRIKAFTA to make up for a missed dose.

Do not take more than the usual dose of TRIKAFTA to make up for a missed dose.

Do not take more than the usual dose of TRIKAFTA to make up for a missed dose.

How Is TRIKAFTA Packaged?

How Is TRIKAFTA Packaged?

How Is TRIKAFTA Packaged?

For children age 6 through 11 years
weighing less than 30 kg (~66 lb)

For children age 6 through 11 years
weighing 30 kg (~66 lb) or more

and people age 12 years and older

Not actual size.

  • Each box of TRIKAFTA has 4 weekly blister cards
  • Each blister card contains 21 tablets:
    2 light orange tablets for each morning and 1 light blue tablet for each evening 

Here are illustrations of the TRIKAFTA tablets next to an illustration of a pistachio.

The light orange tablet is approximately 12 mm by 6 mm.

The light orange tablet is approximately 12 mm by 6 mm.

The light orange tablet is approximately 12 mm by 6 mm.

The light blue tablet is approximately 13 mm by 7 mm.

The light blue tablet is approximately 13 mm by 7 mm.

The light blue tablet is approximately 13 mm by 7 mm.

Not actual size.

  • Each box of TRIKAFTA has 4 weekly blister cards
  • Each blister card contains 21 tablets:
    2 orange tablets for each morning and 1 light blue tablet for each evening 

Here are illustrations of the TRIKAFTA tablets next to an illustration of a pistachio.

The orange tablet is approximately 16 mm by 8 mm.

The orange tablet is approximately 16 mm by 8 mm.

The orange tablet is approximately 16 mm by 8 mm.

The light blue tablet is approximately 17 mm by 8 mm.

The light blue tablet is approximately 17 mm by 8 mm.

The light blue tablet is approximately 17 mm by 8 mm.

For children age 6 through
11 years weighing
less than 30 kg (~66 lb)

Not actual size.

  • Each box of TRIKAFTA has 4 weekly blister cards
  • Each blister card contains 21 tablets:
    2 light orange tablets for each morning and 1 light blue tablet for each evening 

Here are illustrations of the TRIKAFTA tablets next to an illustration of a pistachio.

The light orange tablet is approximately 12 mm by 6 mm.

The light orange tablet is approximately 12 mm by 6 mm.

The light orange tablet is approximately 12 mm by 6 mm.

The light blue tablet is approximately 13 mm by 7 mm.

The light blue tablet is approximately 13 mm by 7 mm.

The light blue tablet is approximately 13 mm by 7 mm.

For children age 6 through 11
years weighing
30 kg (~66 lb) or more

and people age 12 years and older

Not actual size.

  • Each box of TRIKAFTA has 4 weekly blister cards
  • Each blister card contains 21 tablets:
    2 orange tablets for each morning and 1 light blue tablet for each evening 

Here are illustrations of the TRIKAFTA tablets next to an illustration of a pistachio.

The orange tablet is approximately 16 mm by 8 mm.

The orange tablet is approximately 16 mm by 8 mm.

The orange tablet is approximately 16 mm by 8 mm.

The light blue tablet is approximately 17 mm by 8 mm.

The light blue tablet is approximately 17 mm by 8 mm.

The light blue tablet is approximately 17 mm by 8 mm.

For help sticking with your TRIKAFTA treatment routine, turn to Vertex GPSTM: Guidance & Patient Support for personalized, one-on-one support.

Learn more

Staying
on Track

Staying
on Track

Staying on Track

with TRIKAFTA

with TRIKAFTA

with TRIKAFTA

Visit Treatment Time in Trilandia (for kids) Get TRIKAFTA dose reminders

Xander, age 27
F508del/F508del

What is TRIKAFTA® (elexacaftor/tezacaftor/ ivacaftor and ivacaftor)?

TRIKAFTA is a prescription medicine used for the treatment of cystic fibrosis (CF) in patients aged 2 years and older who have at least one copy of the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene or another mutation that is responsive to treatment with TRIKAFTA.

Talk to your doctor to learn if you have an indicated CF gene mutation.

It is not known if TRIKAFTA is safe and effective in children under 2 years of age.

IMPORTANT SAFETY INFORMATION

Before taking TRIKAFTA, tell your doctor about all of your medical conditions, including if you:

  • are allergic to TRIKAFTA or any ingredients in TRIKAFTA. See the Patient Information for a list of ingredients
  • have kidney problems
  • have or have had liver problems
  • are pregnant or plan to become pregnant. It is not known if TRIKAFTA will harm your unborn baby. You and your doctor should decide if you will take TRIKAFTA while you are pregnant
  • are breastfeeding or planning to breastfeed. It is not known if TRIKAFTA passes into your breast milk. You and your doctor should decide if you will take TRIKAFTA while you are breastfeeding

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

TRIKAFTA may affect the way other medicines work, and other medicines may affect how TRIKAFTA works. The dose of TRIKAFTA may need to be adjusted when taken with certain medicines. Ask your doctor or pharmacist for a list of these medicines if you are not sure.

Especially tell your doctor if you take:

  • antibiotics such as rifampin (RIFAMATE®, RIFATER®) or rifabutin (MYCOBUTIN®)
  • seizure medicines such as phenobarbital, carbamazepine (TEGRETOL®, CARBATROL®, EQUETRO®), or phenytoin (DILANTIN®, PHENYTEK®)
  • St. John’s wort
  • antifungal medicines including ketoconazole, itraconazole (such as SPORANOX®), posaconazole (such as NOXAFIL®), voriconazole (such as VFEND®), or fluconazole (such as DIFLUCAN®)
  • antibiotics including telithromycin, clarithromycin (such as BIAXIN®), or erythromycin (such as ERY-TAB®)

What should I avoid while taking TRIKAFTA?

  • Avoid food or drink that contains grapefruit while you are taking TRIKAFTA

What are the possible side effects of TRIKAFTA?

TRIKAFTA can cause serious side effects, including:

  • Liver damage and worsening of liver function in people with severe liver disease that can be serious and may require transplantation. Liver damage has also happened in people without liver disease
  • High liver enzymes in the blood, which is a common side effect in people treated with TRIKAFTA. These can be serious and may be a sign of liver injury. Your doctor will do blood tests to check your liver:
  • before you start TRIKAFTA
  • every 3 months during your first year of taking TRIKAFTA
  • every year while you are taking TRIKAFTA

Your doctor may do blood tests to check the liver more often if you have had high liver enzymes in your blood in the past.

Call your doctor right away if you have any of the following symptoms of liver problems:

  • pain or discomfort in the upper right stomach (abdominal) area
  • yellowing of your skin or the white part of your eyes
  • loss of appetite
  • nausea or vomiting
  • dark, amber-colored urine
  • Serious allergic reactions have happened to people who are treated with TRIKAFTA. Call your healthcare provider or go to the emergency room right away if you have any symptoms of an allergic reaction. Symptoms of an allergic reaction may include:
  • rash or hives
  • tightness of the chest or throat or difficulty breathing
  • swelling of the face, lips, and/or tongue, or difficulty swallowing
  • light-headedness or dizziness
  • Abnormality of the eye lens (cataract), which has happened in some children and adolescents treated with TRIKAFTA. If you are a child or adolescent, your doctor should perform eye examinations before and during treatment with TRIKAFTA to look for cataracts

The most common side effects of TRIKAFTA include:

  • headache
  • upper respiratory tract infection (common cold) including stuffy and runny nose
  • stomach (abdominal) pain
  • diarrhea
  • rash
  • increase in liver enzymes
  • increase in a certain blood enzyme called creatine phosphokinase
  • flu (influenza)
  • inflamed sinuses
  • increase in blood bilirubin

Tell your doctor if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of TRIKAFTA. For more information, ask your doctor or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

For further information, please see full Prescribing Information, including Patient Information.

Arrow icon arrow icon

Important Safety Information and Indication

Información Importante de Seguridad e Indicación

EXPAND

AMPLIAR

COLLAPSE

REDUCIR

What is TRIKAFTA® (elexacaftor/tezacaftor/ ivacaftor and ivacaftor)?

TRIKAFTA is a prescription medicine used for the treatment of cystic fibrosis (CF) in patients aged 2 years and older who have at least one copy of the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene or another mutation that is responsive to treatment with TRIKAFTA.

Talk to your doctor to learn if you have an indicated CF gene mutation.

It is not known if TRIKAFTA is safe and effective in children under 2 years of age.

IMPORTANT SAFETY INFORMATION

Before taking TRIKAFTA, tell your doctor about all of your medical conditions, including if you:

  • are allergic to TRIKAFTA or any ingredients in TRIKAFTA. See the Patient Information for a list of ingredients
  • have kidney problems
  • have or have had liver problems
  • are pregnant or plan to become pregnant. It is not known if TRIKAFTA will harm your unborn baby. You and your doctor should decide if you will take TRIKAFTA while you are pregnant
  • are breastfeeding or planning to breastfeed. It is not known if TRIKAFTA passes into your breast milk. You and your doctor should decide if you will take TRIKAFTA while you are breastfeeding

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

TRIKAFTA may affect the way other medicines work, and other medicines may affect how TRIKAFTA works. The dose of TRIKAFTA may need to be adjusted when taken with certain medicines. Ask your doctor or pharmacist for a list of these medicines if you are not sure.

Especially tell your doctor if you take:

  • antibiotics such as rifampin (RIFAMATE®, RIFATER®) or rifabutin (MYCOBUTIN®)
  • seizure medicines such as phenobarbital, carbamazepine (TEGRETOL®, CARBATROL®, EQUETRO®), or phenytoin (DILANTIN®, PHENYTEK®)
  • St. John’s wort
  • antifungal medicines including ketoconazole, itraconazole (such as SPORANOX®), posaconazole (such as NOXAFIL®), voriconazole (such as VFEND®), or fluconazole (such as DIFLUCAN®)
  • antibiotics including telithromycin, clarithromycin (such as BIAXIN®), or erythromycin (such as ERY-TAB®)

What should I avoid while taking TRIKAFTA?

  • Avoid food or drink that contains grapefruit while you are taking TRIKAFTA

What are the possible side effects of TRIKAFTA?

TRIKAFTA can cause serious side effects, including:

  • Liver damage and worsening of liver function in people with severe liver disease that can be serious and may require transplantation. Liver damage has also happened in people without liver disease
  • High liver enzymes in the blood, which is a common side effect in people treated with TRIKAFTA. These can be serious and may be a sign of liver injury. Your doctor will do blood tests to check your liver:
  • before you start TRIKAFTA
  • every 3 months during your first year of taking TRIKAFTA
  • every year while you are taking TRIKAFTA

Your doctor may do blood tests to check the liver more often if you have had high liver enzymes in your blood in the past.

Call your doctor right away if you have any of the following symptoms of liver problems:

  • pain or discomfort in the upper right stomach (abdominal) area
  • yellowing of your skin or the white part of your eyes
  • loss of appetite
  • nausea or vomiting
  • dark, amber-colored urine
  • Serious allergic reactions have happened to people who are treated with TRIKAFTA. Call your healthcare provider or go to the emergency room right away if you have any symptoms of an allergic reaction. Symptoms of an allergic reaction may include:
  • rash or hives
  • tightness of the chest or throat or difficulty breathing
  • swelling of the face, lips, and/or tongue, or difficulty swallowing
  • light-headedness or dizziness
  • Abnormality of the eye lens (cataract), which has happened in some children and adolescents treated with TRIKAFTA. If you are a child or adolescent, your doctor should perform eye examinations before and during treatment with TRIKAFTA to look for cataracts

The most common side effects of TRIKAFTA include:

  • headache
  • upper respiratory tract infection (common cold) including stuffy and runny nose
  • stomach (abdominal) pain
  • diarrhea
  • rash
  • increase in liver enzymes
  • increase in a certain blood enzyme called creatine phosphokinase
  • flu (influenza)
  • inflamed sinuses
  • increase in blood bilirubin

Tell your doctor if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of TRIKAFTA. For more information, ask your doctor or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

For further information, please see full Prescribing Information, including Patient Information.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

TRIKAFTA may affect the way other medicines work, and other medicines may affect how TRIKAFTA works. The dose of TRIKAFTA may need to be adjusted when taken with certain medicines. Ask your doctor or pharmacist for a list of these medicines if you are not sure.

Especially tell your doctor if you take:

  • antibiotics such as rifampin (RIFAMATE®, RIFATER®) or rifabutin (MYCOBUTIN®)
  • seizure medicines such as phenobarbital, carbamazepine (TEGRETOL®, CARBATROL®, EQUETRO®), or phenytoin (DILANTIN®, PHENYTEK®)
  • St. John’s wort
  • antifungal medicines including ketoconazole, itraconazole (such as SPORANOX®), posaconazole (such as NOXAFIL®), voriconazole (such as VFEND®), or fluconazole (such as DIFLUCAN®)
  • antibiotics including telithromycin, clarithromycin (such as BIAXIN®), or erythromycin (such as ERY-TAB®)

What should I avoid while taking TRIKAFTA?

  • Avoid food or drink that contains grapefruit while you are taking TRIKAFTA

What are the possible side effects of TRIKAFTA?

TRIKAFTA can cause serious side effects, including:

  • Liver damage and worsening of liver function in people with severe liver disease that can be serious and may require transplantation. Liver damage has also happened in people without liver disease
  • High liver enzymes in the blood, which is a common side effect in people treated with TRIKAFTA. These can be serious and may be a sign of liver injury. Your doctor will do blood tests to check your liver:
  • before you start TRIKAFTA
  • every 3 months during your first year of taking TRIKAFTA
  • every year while you are taking TRIKAFTA

Your doctor may do blood tests to check the liver more often if you have had high liver enzymes in your blood in the past.

Call your doctor right away if you have any of the following symptoms of liver problems:

  • pain or discomfort in the upper right stomach (abdominal) area
  • yellowing of your skin or the white part of your eyes
  • loss of appetite
  • nausea or vomiting
  • dark, amber-colored urine
  • Serious allergic reactions have happened to people who are treated with TRIKAFTA. Call your healthcare provider or go to the emergency room right away if you have any symptoms of an allergic reaction. Symptoms of an allergic reaction may include:
  • rash or hives
  • tightness of the chest or throat or difficulty breathing
  • swelling of the face, lips, and/or tongue, or difficulty swallowing
  • light-headedness or dizziness
  • Abnormality of the eye lens (cataract), which has happened in some children and adolescents treated with TRIKAFTA. If you are a child or adolescent, your doctor should perform eye examinations before and during treatment with TRIKAFTA to look for cataracts

The most common side effects of TRIKAFTA include:

  • headache
  • upper respiratory tract infection (common cold) including stuffy and runny nose
  • stomach (abdominal) pain
  • diarrhea
  • rash
  • increase in liver enzymes
  • increase in a certain blood enzyme called creatine phosphokinase
  • flu (influenza)
  • inflamed sinuses
  • increase in blood bilirubin

Tell your doctor if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of TRIKAFTA. For more information, ask your doctor or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

For further information, please see full Prescribing Information, including Patient Information.